Double screening of suramin derivatives on human colon cancer cells and on neural cells provides new therapeutic agents with reduced toxicity
S Baghdiguian, P Nickel, J Fantini - Cancer letters, 1991 - Elsevier
Suramin is a polyanionic compound currently used under evaluation for antineoplastic
activity. One of the main problems encountered during clinical trials was an adverse
neurotoxic effect, probably due to a direct cytotoxic effect on neural cells. Suramin is also
known to trigger differentiation of human colon cancer cells, yet a chronic treatment induces
a lysosomal storage disorder. The aim of this study was to evaluate suramin analogs for their
effect:(i) on the lysosomal system of the human colon cancer cell clone HT29-D4; and (ii) on …
activity. One of the main problems encountered during clinical trials was an adverse
neurotoxic effect, probably due to a direct cytotoxic effect on neural cells. Suramin is also
known to trigger differentiation of human colon cancer cells, yet a chronic treatment induces
a lysosomal storage disorder. The aim of this study was to evaluate suramin analogs for their
effect:(i) on the lysosomal system of the human colon cancer cell clone HT29-D4; and (ii) on …
以上显示的是最相近的搜索结果。 查看全部搜索结果